Biocatalytic Reduction Reactions from a Chemist's Perspective
Frank Hollmann (TU Delft - BT/Biocatalysis, University of the Free State)
Diederik J. Opperman (University of the Free State)
Caroline Paul (TU Delft - BT/Biocatalysis)
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Abstract
Reductions play a key role in organic synthesis, producing chiral products with new functionalities. Enzymes can catalyse such reactions with exquisite stereo-, regio- and chemoselectivity, leading the way to alternative shorter classical synthetic routes towards not only high-added-value compounds but also bulk chemicals. In this review we describe the synthetic state-of-the-art and potential of enzymes that catalyse reductions, ranging from carbonyl, enone and aromatic reductions to reductive aminations.
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