Selective Peroxygenase-Catalysed Oxidation of Toluene Derivates to Benzaldehydes
Yutong Wang (TU Delft - BT/Biocatalysis, Tianjin University)
Niklas Teetz (University of Applied Sciences Mittelhessen)
Dirk Holtmann (University of Applied Sciences Mittelhessen)
Miguel Alcalde (Instituto de Catálisis y Petroleoquímica - CSIC)
Jacob M.A. van Hengst (TU Delft - BT/Biocatalysis)
Xiaoxiao Liu (Chinese Academy of Sciences)
Mengfan Wang (Tianjin University)
Wei Qi (Tianjin University)
Wuyuan Zhang (Chinese Academy of Sciences)
Frank Hollmann (TU Delft - BT/Biocatalysis)
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Abstract
Biocatalytic oxidation reactions of toluene derivates to the corresponding aldehydes are typically challenged by regio- and chemoselectivity issues. In this contribution we address both challenges by a combined reactant- and reaction engineering approach. We demonstrate that the peroxygenase-catalysed transformation of ring-substituted toluenes proceeds highly regioselectively in benzylic position. Furthermore, neat reaction conditions not only enable attractive product concentrations (up to 185 mM) but also result in highly chemoselective oxidations to the aldehyde level.
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