Photoelectroenzymatic Oxyfunctionalization on Flavin-Hybridized Carbon Nanotube Electrode Platform
Da Som Choi (Korea Advanced Institute of Science and Technology)
Y. Ni (TU Delft - BT/Biocatalysis)
Elena Fueyo (TU Delft - BT/Biocatalysis)
Minah Lee (Korea Advanced Institute of Science and Technology)
F. Hollmann (TU Delft - BT/Biocatalysis)
Chan Park (Korea Advanced Institute of Science and Technology)
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Abstract
Peroxygenases are very promising catalysts for oxyfunctionalization reactions. Their practical applicability, however, is hampered by their sensitivity against the oxidant (H2O2), therefore necessitating in situ generation of H2O2. Here, we report a photoelectrochemical approach to provide peroxygenases with suitable amounts of H2O2 while reducing the electrochemical overpotential needed for the reduction of molecular oxygen to H2O2. When tethered on single-walled carbon nanotubes (SWNTs) under illumination, flavins allowed for a marked anodic shift of the oxygen reduction potential in comparison to pristine SWNT and/or nonilluminated electrodes. This flavin-SWNT-based photoelectrochemical platform enabled peroxygenases-catalyzed, selective hydroxylation reactions.