Advancing single-molecule instrumentation through nanoscale optics, fabrication, and surface functionalization

Doctoral thesis (2018)

Authors

S. Ha BN/Nynke Dekker Lab - AS
Research Group
BN/Nynke Dekker Lab (AS) (TU Delft)
Copyright: © 2018 S. Ha
DOI
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https://doi.org/10.4233/uuid:addc45be-225e-4a52-acb6-59b3c967deb1
Biophysics Optical tweezers Single-molecule Nanofabrication Surface functionalization Fluorescence microscopy Optical torque wrench Nano-optics DNA nanocurtain
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Published Date

2018

Language

English

Faculty

Applied Sciences

Department

BN/Bionanoscience

Research Group

BN/Nynke Dekker Lab

Abstract

This thesis describes developments in the single-molecule instrumentation, in particular optical torque wrench and DNA nanocurtains, with the goal of employing these techniques in studies of biomolecules and biomotors. Importantly, the use of single-crystal rutile titanium dioxide nanocylinders is suggested for optical torque wrench, enabling access to a larger torque-speed space and improvement in spatiotemporal resolution.