Study of Time-Resolved Dynamics in Turbid Medium Using a Single-Cavity Dual-Comb Laser
B. Zhang (TU Delft - Optical Technologies)
Christopher Phillips (ETH Zürich)
E. Venialgo (TU Delft - Optical Technologies)
S. Iskander-Rizk (TU Delft - Optical Technologies)
Justinas Pupeikis (ETH Zürich)
Benjamin Willenberg (ETH Zürich)
Ursula Keller (ETH Zürich)
N Bhattacharya (TU Delft - Optical Technologies)
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Abstract
In measuring cerebral blood flow (CBF) noninvasively using optical techniques, diffusing-wave spectroscopy is often combined with near-infrared spectroscopy to obtain a reliable blood flow index. Measuring the blood flow index at a determined depth remains the ultimate goal. In this study, we present a simple approach using dual-comb lasers where we simultaneously measure the absorption coefficient (μa), the reduced scattering coefficient (μs′), and dynamic properties. This system can also effectively differentiate dynamics from various depths, which is crucial for analyzing multilayer dynamics. For CBF measurements, this capability is particularly valuable as it helps mitigate the influence of the scalp and skull, thereby enhancing the specificity of deep tissue.
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