MRI Contrast Agents in Glycobiology
Carlos F.G.C. Geraldes (Universidade de Coimbra, CIBIT-Coimbra Institute for Biomedical Imaging and Translational Research, Coimbra)
Joop Peters (TU Delft - BT/Biocatalysis)
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Abstract
Molecular recognition involving glycoprotein-mediated interactions is ubiquitous in both normal and pathological natural processes. Therefore, visualization of these interactions and the extent of expression of the sugars is a challenge in medical diagnosis, monitoring of therapy, and drug design. Here, we review the literature on the development and validation of probes for magnetic resonance imaging using carbohydrates either as targeting vectors or as a target. Lectins are important targeting vectors for carbohydrate end groups, whereas selectins, the asialoglycoprotein receptor, sialic acid end groups, hyaluronic acid, and glycated serum and hemoglobin are interesting carbohydrate targets.
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