Atomic scale surface engineering of micro- to nano-sized pharmaceutical particles for drug delivery applications

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Atomic scale surface engineering of micro- to nano-sized pharmaceutical particles for drug delivery applications

Journal Article (2017)

Author(s)

D. Zhang (AstraZeneca)

M. J. Quayle (AstraZeneca)

G. Petersson (AstraZeneca)

J. R. Van Ommen (TU Delft - Applied Sciences)

S. Folestad (AstraZeneca)

Research Group

ChemE/Product and Process Engineering

DOI related publication

https://doi.org/10.1039/c7nr03261g Final published version

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https://resolver.tudelft.nl/uuid:b31edac3-91d6-4e18-a105-71b5be7f5d49

More Info

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Publication Year

2017

Language

English

Research Group

ChemE/Product and Process Engineering

Issue number

32

Volume number

9

Pages (from-to)

11410-11417

Downloads counter

196

Abstract

Atomic layer deposition on pharmaceutical particles for drug delivery applications is demonstrated using assisted fluidized bed dry powder processing. Complete and conformal layering is achieved on particle sizes from the lower micron to upper nanometer range under near ambient conditions. As few as 2-14 atomic alumina layers alter particle properties: dissolution, dispersibility and heat transfer.