Short-term interactions between Staphylococcus aureus and Pseudomonas aeruginosa
BEP Report
J. van der Poel (TU Delft - Electrical Engineering, Mathematics and Computer Science)
T. Idema – Mentor (TU Delft - BN/Timon Idema Lab)
J.L.A. Dubbeldam – Mentor (TU Delft - Mathematical Physics)
J.W. Zwanikken – Graduation committee member (TU Delft - BN/Jos Zwanikken Lab)
Dion Gijswijt – Graduation committee member (TU Delft - Discrete Mathematics and Optimization)
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Abstract
Staphylococcus aureus and Pseudomonas aeruginosa are two species of bacteria that are involved in numerous conditions, including lung infections and chronic wound infections. The aim of this project was to study the short-term interactions that occur when P. aeruginosa first encounters an established S. aureus colony, which it then seeks to break apart whilst mixing with S. aureus. Limoli et al. have studied these interactions using experiments, and have thus identified several key aspects involved in these interactions, such as the mechanisms that P. aeruginosa employs to approach the S. aureus colony. The means by which we intended to study interactions between S. aureus and P. aeruginosa is a model that was made by previous members of the Idema group and that was based on the experiments by Limoli et al. In this report, we discuss this model and the biological background relevant to it. We also document the problems that we encountered while trying to run simulations using an existing implementation of this model.