Shrinking a bottleneck in cryo-EM sample preparation
Arjen J. Jakobi (TU Delft - Applied Sciences, Kavli institute of nanoscience Delft)
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Abstract
In a recent issue of Nature Methods , Eluru et al. 1 describe a microfluidic approach that integrates protein purification with cryogenic electron microscopy (cryo-EM) grid preparation to enable high-resolution single-particle cryo-EM structure determination from minute amounts of starting material.
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