Synthesis of 197m/gHg labelled gold nanoparticles for targeted radionuclide therapy
Philipp Droop (FH Aachen University of Applied Sciences, TRIUMF)
Shaohuang Chen (Simon Fraser University, TRIUMF)
Melissa J. Radford (Simon Fraser University)
Elisabeth Paulssen (TU Delft - RST/Applied Radiation & Isotopes, FH Aachen University of Applied Sciences)
Byron D. Gates (Simon Fraser University)
Raymond M. Reilly (University of Toronto)
Valery Radchenko (TRIUMF, University of British Columbia)
Cornelia Hoehr (TRIUMF)
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Abstract
Meitner-Auger-electron emitters have a promising potential for targeted radionuclide therapy of cancer because of their short range and the high linear energy transfer of Meitner-Auger-electrons (MAE). One promising MAE candidate is 197m/gHg with its half-life of 23.8 » h and 64.1 » h, respectively, and high MAE yield. Gold nanoparticles (AuNPs) that are labelled with 197m/gHg could be a helpful tool for radiation treatment of glioblastoma multiforme when infused into the surgical cavity after resection to prevent recurrence. To produce such AuNPs, 197m/gHg was embedded into pristine AuNPs. Two different syntheses were tested starting from irradiated gold containing trace amounts of 197m/gHg. When sodium citrate was used as reducing agent, no 197m/gHg labelled AuNPs were formed, but with tannic acid, 197m/gHg labeled AuNPs were produced. The method was optimized by neutralizing the pH (pH = 7) of the Au/197m/gHg solution, which led to labelled AuNPs with a size of 12.3 ± 2.0 » nm as measured by transmission electron microscopy. The labelled AuNPs had a concentration of 50 » μg (gold)/mL with an activity of 151 ± 93 » kBq/mL (197gHg, time corrected to the end of bombardment).