Synthesis of <sup>197m/g</sup>Hg labelled gold nanoparticles for targeted radionuclide therapy

Journal article (2023)

Authors

Philipp Droop TRIUMF, FH Aachen University of Applied Sciences
Shaohuang Chen TRIUMF, Simon Fraser University
Melissa J. Radford Simon Fraser University
E. Paulssen FH Aachen University of Applied Sciences, RST/Applied Radiation & Isotopes - AS
Byron D. Gates Simon Fraser University
Raymond M. Reilly University of Toronto
Valery Radchenko TRIUMF, University of British Columbia
Research Group
RST/Applied Radiation & Isotopes (AS) (TU Delft)
Copyright: © 2023 Philipp Droop, Shaohuang Chen, Melissa J. Radford, E. Paulssen, Byron D. Gates, Raymond M. Reilly, Valery Radchenko, Cornelia Hoehr
DOI
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https://doi.org/10.1515/ract-2023-0144
Hg Gold nanoparticle (AuNP) Meitner-Auger-electron (MAE) Targeted radionuclide therapy (TRT)
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Published Date

2023

Language

English

Reuse Rights

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Faculty

Applied Sciences

Department

RST/Radiation, Science and Technology

Research Group

RST/Applied Radiation & Isotopes

Abstract

Meitner-Auger-electron emitters have a promising potential for targeted radionuclide therapy of cancer because of their short range and the high linear energy transfer of Meitner-Auger-electrons (MAE). One promising MAE candidate is 197m/gHg with its half-life of 23.8 » h and 64.1 » h, respectively, and high MAE yield. Gold nanoparticles (AuNPs) that are labelled with 197m/gHg could be a helpful tool for radiation treatment of glioblastoma multiforme when infused into the surgical cavity after resection to prevent recurrence. To produce such AuNPs, 197m/gHg was embedded into pristine AuNPs. Two different syntheses were tested starting from irradiated gold containing trace amounts of 197m/gHg. When sodium citrate was used as reducing agent, no 197m/gHg labelled AuNPs were formed, but with tannic acid, 197m/gHg labeled AuNPs were produced. The method was optimized by neutralizing the pH (pH = 7) of the Au/197m/gHg solution, which led to labelled AuNPs with a size of 12.3 ± 2.0 » nm as measured by transmission electron microscopy. The labelled AuNPs had a concentration of 50 » μg (gold)/mL with an activity of 151 ± 93 » kBq/mL (197gHg, time corrected to the end of bombardment).