Cross-validated Cox regression on microarray gene expression data

Journal article (2006)

Authors

HC van Houwelingen External organisation
T Bruinsma External organisation
AAM Hart External organisation
LJ van 't Veer External organisation
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Published Date

2006

Language

Undefined/Unknown

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Abstract

This paper describes how penalized Cox regression, in combination with cross-validated partial likelihood can be employed to obtain reliable survival prediction models for high dimensional microarray data. The suggested procedure is demonstrated on a breast cancer survival data set consisting of 295 tumours as collected in the National Cancer Institute in Amsterdam and previously reported in more general papers.
The main aim of this paper it to show how generally accepted biostatistical procedures can be employed to analyse high-dimensional data. Copyright © 2005 John Wiley & Sons, Ltd.