Conditional flux balance analysis toolbox for python

application to research metabolism in cyclic environments

Journal Article (2024)
Author(s)

Timothy Páez-Watson (TU Delft - Applied Sciences)

Ricardo Hernández Medina

Loek Vellekoop (Student TU Delft)

Mark C.M. van Loosdrecht (TU Delft - Applied Sciences)

S. Aljoscha Wahl (Friedrich-Alexander-Universität Erlangen-Nürnberg, TU Delft - Applied Sciences)

Research Group
BT/Environmental Biotechnology
DOI related publication
https://doi.org/10.1093/bioadv/vbae174 Final published version
More Info
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Publication Year
2024
Language
English
Research Group
BT/Environmental Biotechnology
Journal title
Bioinformatics Advances
Issue number
1
Volume number
4
Article number
vbae174
Downloads counter
288
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Abstract

We present py_cFBA, a Python-based toolbox for conditional flux balance analysis (cFBA). Our toolbox allows for an easy implementation of cFBA models using a well-documented and modular approach and supports the generation of Systems Biology Markup Language models. The toolbox is designed to be user-friendly, versatile, and freely available to non-commercial users, serving as a valuable resource for researchers predicting metabolic behaviour with resource allocation in dynamic-cyclic environments.