Synthesis of enantiomerically pure alcohols and amines
Via biocatalytic deracemisation methods
Musa M. Musa (King Fahd University of Petroleum and Minerals)
Frank Hollmann (TU Delft - BT/Biocatalysis)
Francesco G. Mutti (Universiteit van Amsterdam)
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Abstract
Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation approaches applied to the synthesis of enantiomerically pure alcohols and amines, such as (1) dynamic kinetic resolution, (2) cyclic deracemisation, (3) linear deracemisation (including stereoinversion) and (4) enantioconvergent methods.
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