A robust chemo-enzymatic lactone synthesis using acyltransferase from Mycobacterium smegmatis

Journal Article (2016)

Authors

A. Drozdz (Silesian University of Technology)

U Hanefeld (TU Delft - BT/Biocatalysis)

K. Szymańska (Silesian University of Technology)

Andrzej Jarzȩbski (Silesian University of Technology, Polish Academy of Sciences)

A. Chrobok (Silesian University of Technology)

Research Group

BT/Biocatalysis

Hydrogen peroxide Baeyer-Villiger oxidation Acyltransferase Lactones

To reference this document use:

https://doi.org/10.1016/j.catcom.2016.03.021

TU Delft Repository resolver:

https://resolver.tudelft.nl/cd8e70ce-4062-4c65-b221-c0a9d1f79613

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Publication Year

2016

Language

English

Research Group

BT/Biocatalysis

Volume number

Pages (from-to)

37-40

DOI:

https://doi.org/10.1016/j.catcom.2016.03.021

Abstract

The new application of acyltransferase, isolated from Mycobacterium smegmatis for the chemo-enzymatic Baeyer-Villiger oxidation of cyclic ketones to lactones was demonstrated. Acyltransferase exhibited high activity, and high stability under harsh reaction conditions, like oxidation with 60% aq. H₂O₂ at 45°C. This paves the way to a novel robust chemo-enzymatic method for lactone synthesis with high yields.

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