Advanced MR Techniques for Preoperative Glioma Characterization
Part 2
Gilbert Hangel (Christian Doppler Laboratory for Precision Engineering for Automated In-Line Metrology, Medical University of Vienna)
Bárbara Schmitz-Abecassis (Medical Delta, Leiden University Medical Center)
Joana Pinto (University of Oxford)
Nico Sollmann (Technische Universität München, University Hospital Ulm)
Chih Hsien Tseng (TU Delft - ImPhys/Computational Imaging, TU Delft - Medical Delta, TU Delft - ImPhys/Vos group)
Frans Vos (Erasmus MC, TU Delft - Medical Delta, TU Delft - ImPhys/Vos group, TU Delft - ImPhys/Computational Imaging)
Esther Warnert (Erasmus MC)
Marion Smits (TU Delft - Medical Delta, Erasmus MC)
Jan Petr (Institute of Radiation Physics)
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Abstract
Preoperative clinical MRI protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness about the state of the art of advanced MRI techniques in gliomas and their possible clinical translation. This review describes current methods, limits, and applications of advanced MRI for the preoperative assessment of glioma, summarizing the level of clinical validation of different techniques. In this second part, we review magnetic resonance spectroscopy (MRS), chemical exchange saturation transfer (CEST), susceptibility-weighted imaging (SWI), MRI-PET, MR elastography (MRE), and MR-based radiomics applications. The first part of this review addresses dynamic susceptibility contrast (DSC) and dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL), diffusion-weighted MRI, vessel imaging, and magnetic resonance fingerprinting (MRF). Evidence Level: 3. Technical Efficacy: Stage 2.
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