Biosynthesis of cyclic ketones by a H2O2 self-sufficient cascade reaction
Bin Wu (South China University of Technology)
Xiangyun Wang (South China University of Technology)
Bo Yang (South China University of Technology)
Yunjian Ma (South China University of Technology)
Frank Hollmann (TU Delft - BT/Biocatalysis)
Yonghua Wang (Guangdong Youmei Institute of Intelligent Bio-manufacturing Co. Ltd., South China University of Technology)
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Abstract
In the present work we propose a bienzymatic cascade for the oxyfunctionalisation of cycloalkanes to cyclic alcohols/cyclic ketones. By combining a H2O2-dependent peroxygenase with a O2-consuming and H2O2-producing alcohol oxidase an overall aerobic oxidation system was established. A convincing proof-of-concept is presented and some current limitations are outlined.
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