Non-linear parameter estimation of volume sensitivity of the coronary resistance in the isolated canine septum

Conference paper (1996)

Authors

JM Cornelissen OLD Man Machine Systems
J. Dankelman Medical Instruments & Bio-Inspired Technology - Mechanical, Maritime and Materials Engineering
Jos A.E. Spaan Universiteit van Amsterdam
Research Group
Medical Instruments & Bio-Inspired Technology (Mechanical, Maritime and Materials Engineering) (TU Delft)
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Published Date

1996

Language

English

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Faculty

Mechanical, Maritime and Materials Engineering

Department

Biomechanical Engineering

Research Group

Medical Instruments & Bio-Inspired Technology

Abstract

Common parameters to describe the coronary circulation are resistances (Rs) and capacitances (Cs). In six isolated, maximally dilated, perfused, non contracting canine interventricular septa, the Rs and Cs at different pressure levels were estimated by obtaining the inflow-pressure transfer functions (Q/P) and volume-pressure transfer functions (T/P). To interpret the data, simple lumped two compartment RCR models were fitted. Models with fixed resistances could not fit simultaneously Q/P and T/P. Therefore models with volume dependent parameters were tested as well. However, these models had more parameters, which could not be uniquely identified from the data. Many parameter sets, which predicted adequate transfer functions, were created. After comparing these parameter sets, it was concluded that the first resistance and the first capacitance could be estimated, furthermore a relation between the distal capacitance and the volume sensitivity of the third resistance was found: the higher the capacitance, the lower the sensitivity.