Long-term Effect of MPH on White Matter Tracts of Adults with ADHD

An Application of Consistent Model Selection followed by TBSS

Master thesis (2018)

Authors

Y. Wu Applied Sciences

Contributors

F.M. Vos (supervisor 1)
O.G. Filatova (supervisor 2)
Faculty
Applied Sciences
Copyright: © 2018 Yulun Wu
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Published Date

21-06-2018

Language

English

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Faculty

Applied Sciences

Abstract

We focused on analysis of long-term medication influenced white matter tracts based on diffusion-weighted MRI brain images of patients with ADHD disorder. We applied a framework of consistent model selection with Tract-based spatial statistics (TBSS) to give proper and consistent modelling of fiber-crossing in white matter. An orientation atlas was constructed to give an `orientation prior' during the ball-and-2sticks model estimation. Consistent metrics of fiber properties were obtained for each subject and thus statistical power in crossing-fiber region was improved. Besides, we improved this pipeline by optimising orientation prior and by integrating a high-dimensional image registration.

Files

Thesis.pdf
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