Model analysis of the interaction between perfusion pressure, MVO<sub>2</sub> and coronary flow control

Conference paper (1996)

Authors

J. Dankelman Medical Instruments & Bio-Inspired Technology - Mechanical, Maritime and Materials Engineering
Jos A.E. Spaan Universiteit van Amsterdam
Research Group
Medical Instruments & Bio-Inspired Technology (Mechanical, Maritime and Materials Engineering) (TU Delft)
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Published Date

1996

Language

English

Reuse Rights

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Faculty

Mechanical, Maritime and Materials Engineering

Department

Biomechanical Engineering

Research Group

Medical Instruments & Bio-Inspired Technology

Abstract

Changes in coronary perfusion pressure affect coronary arterial resistance (autoregulation) as well as myocardial oxygen consumption (Gregg's phenomenon). The interaction between the effects of perfusion pressure and myocardial oxygen consumption on coronary flow control was investigated using a model. This model analysis predicts that autoregulation and Gregg's phenomenon compete with each other in controlling coronary flow. The negative feedback system of the metabolic control system can become a positive feedback system when the level of arterial tone decreases and Gregg's phenomenon becomes more important.