Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second
Min Wu (Erasmus MC)
Geert Springeling (Erasmus MC)
Matija Lovrak (TU Delft - ChemE/Advanced Soft Matter)
Frits Mastik (Erasmus MC)
Sophinese Iskander-Rizk (Erasmus MC)
Tianshi Wang (Erasmus MC)
Heleen M.M. Van Beusekom (Erasmus MC)
A. F.W. Van Der Steen (ImPhys/Acoustical Wavefield Imaging , Erasmus MC, Chinese Academy of Sciences)
Gijs Van Soest (Erasmus MC)
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Abstract
Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arteries in vivo, at a clinically useful frame rate of 20 s−1. We confirmed image contrast for atherosclerotic plaque in human samples ex vivo. The system is on a mobile platform and provides real-time data visualization during acquisition. We achieved an IVPA signal-to-noise ratio of 20 dB. These data show that clinical translation of IVPA is possible in principle.
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