Simulation-based validation of the physical model in 3D polarized light imaging

Conference paper (2015)

Authors

Miriam Menzel Forschungszentrum Jülich
Melanie Dohmen Forschungszentrum Jülich
Hans De Raedt Rijksuniversiteit Groningen
Kristel Michielsen Forschungszentrum Jülich
Katrin Amunts Forschungszentrum Jülich, Universität Düsseldorf
Markus Axer Forschungszentrum Jülich
Affiliation
External organisation
More Info
expand_more

Published Date

2015

Language

English

Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Affiliation

External organisation

Abstract

3D Polarized Light Imaging is a neuroimaging technique that provides a high-resolution reconstruction of nerve fiber pathways in human postmortem brains. The spatial fiber orientations are derived from birefringence measurements of histological brain sections which are interpreted by a macroscopic model of uniaxial birefringence. In order to validate the macroscopic model and to investigate possible limitations, numerical simulations have been used. Simulations of a fiber bundle with different inclination angles and optical resolutions have shown that the macroscopic model ensures a reliable estimation of the fiber orientations as long as the polarimeter does not resolve structures smaller than the fiber radius.