Analysis of urine, oral fluid and fingerprints by liquid extraction surface analysis coupled to high resolution MS and MS/MS - Opportunities for forensic and biomedical science

Journal article (2016)

Authors

Melanie J. Bailey University of Surrey
Elizabeth C. Randall National Physical Laboratory, University of Birmingham
Catia Costa University of Surrey
Tara L. Salter National Physical Laboratory
Alan M. Race National Physical Laboratory
M. de Puit Nederlands Forensisch Instituut (NFI), OLD ChemE/Organic Materials and Interfaces
Mattijs Koeberg Nederlands Forensisch Instituut (NFI)
Mark Baumert Harlow Enterprise Hub
Josephine Bunch National Physical Laboratory, University of Nottingham
Research Group
OLD ChemE/Organic Materials and Interfaces
Copyright: © 2016 Melanie J. Bailey, Elizabeth C. Randall, Catia Costa, Tara L. Salter, Alan M. Race, M. de Puit, Mattijs Koeberg, Mark Baumert, Josephine Bunch
DOI
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https://doi.org/10.1039/c6ay00782a
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Published Date

28-04-2016

Language

English

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Research Group

OLD ChemE/Organic Materials and Interfaces

Abstract

Liquid Extraction Surface Analysis (LESA) is a new, high throughput tool for ambient mass spectrometry. A solvent droplet is deposited from a pipette tip onto a surface and maintains contact with both the surface and the pipette tip for a few seconds before being re-aspirated. The technique is particularly suited to the analysis of trace materials on surfaces due to its high sensitivity and low volume of sample removal. In this work, we assess the suitability of LESA for obtaining detailed chemical profiles of fingerprints, oral fluid and urine, which may be used in future for rapid medical diagnostics or metabolomics studies. We further show how LESA can be used to detect illicit drugs and their metabolites in urine, oral fluid and fingerprints. This makes LESA a potentially useful tool in the growing field of fingerprint chemical analysis, which is relevant not only to forensics but also to medical diagnostics. Finally, we show how LESA can be used to detect the explosive material RDX in contaminated artificial fingermarks.