Wafer-Scale Graphene-Based Soft Electrode Array with Optogenetic Compatibility
Andrada Iulia Velea (TU Delft - Bio-Electronics)
S. Vollebregt (TU Delft - Sanitary Engineering)
G.K. Wardhana (TU Delft - Bio-Electronics)
Vasso Giagka (Fraunhofer Institute for Reliability and Microintegration IZM, TU Delft - Bio-Electronics)
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Abstract
This paper reports on the characterization of a microfabricated wafer-scale, graphene-based, soft implant for spinal cord applications. Graphene is used because of its high transparency and good conductivity, making it suitable for optogenetic applications. Moreover it has a high mechanical strength and is potentially biocompatible. The implant consists of multi-layered chemical vapor deposited graphene, in the form of electrodes and tracks, encapsulated between 2 layers of silicone. Methods such as Raman spectroscopy, optical transmittance, and electrical measurements combined with bending tests and in-vitro experiments, using phosphate-buffered saline (PBS) solution, were employed to characterize the device. The results have shown high bendability and no critical damage of the graphene after immersing the device in PBS solution up to 7 days. To the authors' best knowledge, this is the first work that presents a soft and fully scalable optogenetics-compatible graphene-based spinal cord electrode array.