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Towards Methanol-driven Biocatalytic Oxyfunctionalisation Reactions

Journal Article (2020)
Author(s)

Sébastien Willot (TU Delft - BT/Biocatalysis)

Manh Dat Hoang (Technische Universität München)

C. E. Paul (TU Delft - BT/Biocatalysis)

Miguel Alcalde (Institute of Catalysis, CSIC, Madrid)

Isabel W.C.E. Arends (Universiteit Utrecht)

Andreas S. Bommarius (Georgia Institute of Technology)

Bettina Bommarius (Georgia Institute of Technology)

F Hollmann (TU Delft - BT/Biocatalysis)

Research Group
BT/Biocatalysis
Copyright
© 2020 S.J. Willot, Manh Dat Hoang, C.E. Paul, Miguel Alcalde, I.W.C.E. Arends, Andreas S. Bommarius, Bettina Bommarius, F. Hollmann
DOI related publication
https://doi.org/10.1002/cctc.202000197
More Info
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Publication Year
2020
Language
English
Copyright
© 2020 S.J. Willot, Manh Dat Hoang, C.E. Paul, Miguel Alcalde, I.W.C.E. Arends, Andreas S. Bommarius, Bettina Bommarius, F. Hollmann
Research Group
BT/Biocatalysis
Issue number
10
Volume number
12
Pages (from-to)
2713-2716
Reuse Rights

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Abstract

The novel formate oxidase from Aspergillus oryzae (AoFOx) is a useful catalyst to promote H2O2-dependent oxyfunctionalisation reactions. In this contribution we exploit the substrate promiscuity of AoFOx to fully oxidise methanol and formaldehyde to CO2 and drive peroxygenase-catalysed stereoselective oxyfunctionalisation reactions. The highly atom efficient H2O2 generation system also enabled high catalytic turnover of the peroxygenase production enzyme.