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Towards Methanol-driven Biocatalytic Oxyfunctionalisation Reactions

Journal article (2020)

Authors

S.J. Willot BT/Biocatalysis - AS
Manh Dat Hoang Technische Universität München
C.E. Paul BT/Biocatalysis - AS
Miguel Alcalde Institute of Catalysis, CSIC, Madrid
I.W.C.E. Arends Universiteit Utrecht
Andreas S. Bommarius Georgia Institute of Technology
Bettina Bommarius Georgia Institute of Technology
F. Hollmann BT/Biocatalysis - AS
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2020 S.J. Willot, Manh Dat Hoang, C.E. Paul, Miguel Alcalde, I.W.C.E. Arends, Andreas S. Bommarius, Bettina Bommarius, F. Hollmann
DOI
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https://doi.org/10.1002/cctc.202000197
Biocatalysis Methanol Peroxygenases Formate oxidase Oxyfunctionalisation
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Published Date

2020

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

The novel formate oxidase from Aspergillus oryzae (AoFOx) is a useful catalyst to promote H2O2-dependent oxyfunctionalisation reactions. In this contribution we exploit the substrate promiscuity of AoFOx to fully oxidise methanol and formaldehyde to CO2 and drive peroxygenase-catalysed stereoselective oxyfunctionalisation reactions. The highly atom efficient H2O2 generation system also enabled high catalytic turnover of the peroxygenase production enzyme.