Vanadium-Containing Chloroperoxidase-Catalyzed Versatile Valorization of Phenols and Phenolic Acids

Journal article (2024)

Authors

Huanhuan Li Xi’an Jiaotong University
Peigao Duan Xi’an Jiaotong University
Yawen Huang Chinese Academy of Sciences
Chengsen Cui Chinese Academy of Sciences
F. Hollmann BT/Biocatalysis - AS
Yunjian Ma South China University of Technology
Yonghua Wang South China University of Technology
Jie Zhang Chinese Academy of Sciences
Weidong Liu Chinese Academy of Sciences
Wuyuan Zhang Chinese Academy of Sciences
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2024 Huanhuan Li, Peigao Duan, Yawen Huang, Chengsen Cui, F. Hollmann, Yunjian Ma, Yonghua Wang, Jie Zhang, Weidong Liu, Wuyuan Zhang
DOI
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https://doi.org/10.1021/acscatal.3c05333
Biocatalysis Halogenation Decarboxylation Lignin valorization Vanadium-containing chloroperoxidase
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Published Date

2024

Language

English

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Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

The downstream product transformation of lignin depolymerization is of great interest in the production of high-value aromatic chemicals. However, this transformation is often impeded by chemical oxidation under harsh reaction conditions. In this study, we demonstrate that hypohalites generated in situ by the vanadium-containing chloroperoxidase from Curvularia inaequalis (CiVCPO) can halogenate various electron-rich and electron-poor phenol and phenolic acid substrates. Specifically, CiVCPO enabled decarboxylative halogenation, deformylative halogenation, halogenation, and direct oxidation reactions. The versatile transformation routes for the valorization of phenolic compounds showed up to 99% conversion and 99% selectivity, with a turnover number of 60,700 and a turnover frequency of 60 s-1 for CiVCPO. This study potentially expands the biocatalytic toolbox for lignin valorization.