Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids
Wuyuan Zhang (TU Delft - BT/Biocatalysis)
M. Ma (TU Delft - ChemE/Materials for Energy Conversion and Storage)
Mieke M.E. Huijbers (TU Delft - BT/Biocatalysis)
G.A. Filonenko (TU Delft - ChemE/Inorganic Systems Engineering)
Evgeny Pidko (TU Delft - ChemE/Algemeen, TU Delft - ChemE/Inorganic Systems Engineering)
Morten M.C.H. Van Schie (TU Delft - BT/Biocatalysis)
Sabrina de Boer (DECHEMA Research Institute)
W. A. Smith (TU Delft - ChemE/Materials for Energy Conversion and Storage)
F Hollmann (TU Delft - BT/Biocatalysis)
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Abstract
A recently discovered photodecarboxylase from Chlorella variabilis NC64A ( CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that the decoy molecule approach enables conversion of a broad range of carboxylic acids by filling up the vacant substrate access channel of the photodecarboxylase. These results not only demonstrate a practical application of a unique, photoactivated enzyme but also pave the way to selective production of short-chain alkanes from waste carboxylic acids under mild reaction conditions.
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