A photodecarboxylase from Micractinium conductrix active on medium and short-chain fatty acids

Journal article (2023)

Authors

Yunjian Ma South China University of Technology, Macau University of Science and Technology
Xuanru Zhong South China University of Technology
Bin Wu South China University of Technology
Dongming Lan South China University of Technology
Hao Zhang South China University of Technology
F. Hollmann BT/Biocatalysis - AS
Yonghua Wang Guangdong Youmei Institute of Intelligent Bio-manufacturing Co, Foshan, South China University of Technology
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2023 Yunjian Ma, Xuanru Zhong, Bin Wu, Dongming Lan, Hao Zhang, F. Hollmann, Yonghua Wang
DOI
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https://doi.org/10.1016/S1872-2067(22)64173-1
Fatty acids Heterologous expression Hydrocarbon biofuel McFAP Photodecarboxylase
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Published Date

2023

Language

English

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Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

Hydrocarbons are essential base chemicals as energy carriers and starting materials for chemical manufacture. So-called fatty acid photodecarboxylases (FAPs) represent interesting catalysts for the conversion of natural fatty acids into hydrocarbons thereby giving access to alkanes from renewable feedstock. Today, however, only few FAPs are known. In the current study we report a new FAP from the marine organism Micractinium conductrix (McFAP). In contrast to currently known FAPs McFAP exhibits high catalytic activity towards short and medium fatty acids. Recombinant expression and basic biochemical characterisation of this new member of the FAP family is reported.