Unifying theories in high-dimensional biophysics

approaches, challenges and opportunities

Journal Article (2026)
Author(s)

Marianne Bauer (TU Delft - Applied Sciences, Kavli institute of nanoscience Delft)

Akshit Goyal (Tata Institute of Fundamental Research)

Sidhartha Goyal (University of Toronto)

Gautam Reddy (Princeton University)

Shaon Chakrabarti (Tata Institute of Fundamental Research)

Michael M. Desai (Harvard University)

William Gilpin (The University of Texas at Austin)

Jacopo Grilli (The Abdus Salam International Centre for Theoretical Physics, Trieste)

Sanjay Jain (Santa Fe Institute, University of Delhi)

More Authors (External organisation)

Research Group
BN/Marianne Bauer Lab
DOI related publication
https://doi.org/10.1038/s41540-026-00680-9 Final published version
More Info
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Publication Year
2026
Language
English
Research Group
BN/Marianne Bauer Lab
Journal title
npj systems biology and applications
Issue number
1
Volume number
12
Article number
43
Downloads counter
18
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Abstract

Across biological subdisciplines, the last decade has seen an explosion of high-dimensional datasets. At the ICTS workshop ‘Unifying Theories in High-Dimensional Biophysics’, we discussed whether this high dimensionality poses a challenge or an opportunity for theoretically describing, understanding and predicting biological systems. We discussed methods, models and frameworks that can be used for this purpose. This Comment summarizes our discussions from the perspectives of individual participants.