Redox cycling in nanofluidic channels using interdigitated electrodes

Goluch, E.D.; Wolfrum, B.; Singh, P.S.; Zevenbergen, M.A.G.; Lemay, S.G.

Redox cycling in nanofluidic channels using interdigitated electrodes

Title

Redox cycling in nanofluidic channels using interdigitated electrodes

Author

Goluch, E.D.
Wolfrum, B.
Singh, P.S.
Zevenbergen, M.A.G.
Lemay, S.G.

Faculty

Applied Sciences

Department

Bionanoscience

Date

2009-01-06

Abstract

Amperometric detection is ideally suited for integration into micro- and nanofluidic systems as it directly yields an electrical signal and does not necessitate optical components. However, the range of systems to which it can be applied is constrained by the limited sensitivity and specificity of the method. These limitations can be partially alleviated through the use of redox cycling, in which multiple electrodes are employed to repeatedly reduce and oxidize analyte molecules and thereby amplify the detected signal. We have developed an interdigitated electrode device that is encased in a nanofluidic channel to provide a hundred-fold amplification of the amperometric signal from paracetamol. Due to the nanochannel design, the sensor is resistant to interference from molecules undergoing irreversible redox reactions. We demonstrate this selectivity by detecting paracetamol in the presence of excess ascorbic acid.

Subject

Nanotechnology
Nanofluidic
Electrochemistry
Amperometric detection
Redox cycling
Interdigitated electrodes (IDEs)
Paracetamol
Ascorbic acid
Sensor

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http://resolver.tudelft.nl/uuid:15761e03-0f57-4763-8452-c02f04ca5ac8

Publisher

Springer

ISSN

1618-2650

Source

Analytical and Bioanalytical Chemistry, 394 (2)

Part of collection

Institutional Repository