Print Email Facebook Twitter Comparing the greenness and sustainability of three routes to an HIV protease inhibitor intermediate Title Comparing the greenness and sustainability of three routes to an HIV protease inhibitor intermediate Author Akakios, Stephanie Gina (University of the Witwatersrand) Bode, Moira Leanne (University of Witwatersrand) Sheldon, R.A. (TU Delft BT/Biocatalysis; University of Witwatersrand) Date 2021 Abstract The greenness and sustainability of three different routes for the synthesis of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-ol (bis-furan alcohol), an advanced intermediate for a group of HIV protease inhibitors, including the FDA approved darunavir, used in antiretroviral (ARV) therapy, were compared. The method involved a comparison of (i) waste generated using theE-factor and relative to industrial benchmarks using the innovative Green Aspiration Level (iGAL™) method, (ii) solvent usage on the basis of solvent intensity (SI) and properties according to the GSK solvent guide, and (iii) Green Motion™ scores according to the MANE methodology. To reference this document use: http://resolver.tudelft.nl/uuid:1b4c2a3c-e3bc-4df5-803d-cfe894062ee2 DOI https://doi.org/10.1039/d1gc00986a ISSN 1463-9262 Source Green Chemistry, 23 (9), 3334-3347 Part of collection Institutional Repository Document type journal article Rights © 2021 Stephanie Gina Akakios, Moira Leanne Bode, R.A. Sheldon Files PDF d1gc00986a.pdf 3.41 MB Close viewer /islandora/object/uuid:1b4c2a3c-e3bc-4df5-803d-cfe894062ee2/datastream/OBJ/view