Print Email Facebook Twitter The correlation between neuropathology levels and cognitive performance in centenarians Title The correlation between neuropathology levels and cognitive performance in centenarians Author Zhang, M. (TU Delft Pattern Recognition and Bioinformatics; Vrije Universiteit Amsterdam) Ganz, Andrea B. (Vrije Universiteit Amsterdam) Rohde, Susan (Vrije Universiteit Amsterdam) Lorenz, Linda (Vrije Universiteit Amsterdam) Rozemuller, Annemieke J.M. (Netherlands Institute for Neuroscience NIN - KNAW) Reinders, M.J.T. (TU Delft Pattern Recognition and Bioinformatics) Hulsman, M. (TU Delft Pattern Recognition and Bioinformatics; Vrije Universiteit Amsterdam) Hoozemans, Jeroen J.M. (Vrije Universiteit Amsterdam) Holstege, H. (Vrije Universiteit Amsterdam; Alzheimer Center Amsterdam) Date 2023 Abstract INTRODUCTION: Neuropathological substrates associated with neurodegeneration occur in brains of the oldest old. How does this affect cognitive performance?. METHODS: The 100-plus Study is an ongoing longitudinal cohort study of centenarians who self-report to be cognitively healthy; post mortem brain donation is optional. In 85 centenarian brains, we explored the correlations between the levels of 11 neuropathological substrates with ante mortem performance on 12 neuropsychological tests. RESULTS: Levels of neuropathological substrates varied: we observed levels up to Thal-amyloid beta phase 5, Braak-neurofibrillary tangle (NFT) stage V, Consortium to Establish a Registry for Alzheimer's Disease (CERAD)-neuritic plaque score 3, Thal-cerebral amyloid angiopathy stage 3, Tar-DNA binding protein 43 (TDP-43) stage 3, hippocampal sclerosis stage 1, Braak-Lewy bodies stage 6, atherosclerosis stage 3, cerebral infarcts stage 1, and cerebral atrophy stage 2. Granulovacuolar degeneration occurred in all centenarians. Some high performers had the highest neuropathology scores. DISCUSSION: Only Braak-NFT stage and limbic-predominant age-related TDP-43 encephalopathy (LATE) pathology associated significantly with performance across multiple cognitive domains. Of all cognitive tests, the clock-drawing test was particularly sensitive to levels of multiple neuropathologies. To reference this document use: http://resolver.tudelft.nl/uuid:230b0a4d-41bc-416e-b306-4346e7ffcdd8 DOI https://doi.org/10.1002/alz.13087 ISSN 1552-5260 Source Alzheimer's & Dementia, 19 (11), 5036-5047 Part of collection Institutional Repository Document type journal article Rights © 2023 M. Zhang, Andrea B. Ganz, Susan Rohde, Linda Lorenz, Annemieke J.M. Rozemuller, M.J.T. Reinders, M. Hulsman, Jeroen J.M. Hoozemans, H. Holstege, More Authors Files PDF Alzheimer_s_Dementia_2023 ... nce_in.pdf 2.03 MB Close viewer /islandora/object/uuid:230b0a4d-41bc-416e-b306-4346e7ffcdd8/datastream/OBJ/view