A cerium-based metal-organic framework as adsorbent for the 99Mo/99mTc generator

Journal article (2022)

Authors

C. Ma RST/Applied Radiation & Isotopes - AS
H.T. Wolterbeek RST/Applied Radiation & Isotopes - AS
A.G. Denkova RST/Applied Radiation & Isotopes - AS
Antonia G. Denkova RST/Applied Radiation & Isotopes - AS
Antonia Denkova RST/Applied Radiation & Isotopes - AS
P. Serra Crespo RST/Applied Radiation & Isotopes - AS
Research Group
RST/Applied Radiation & Isotopes (AS) (TU Delft)
Copyright: © 2022 C. Ma, H.T. Wolterbeek, A.G. Denkova, P. Serra Crespo
DOI: https://doi.org/10.1016/j.seppur.2022.121218
More Info
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Published Date

2022

Language

English

Faculty

Applied Sciences

Department

RST/Radiation, Science and Technology

Research Group

RST/Applied Radiation & Isotopes

Abstract

The cerium-based metal–organic framework UiO-66 (Ce) was examined as a potential adsorbent for the 99Mo/99mTc generator. The results showed that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. An adsorption mechanism was proposed, where the adsorption was governed by hydrogen bonds, Ce-O-Mo coordination, π-anions and electrostatic interaction. Additionally, the adsorbent exhibited excellent radiation stability and good adsorption performance when radioactive 99Mo was applied. A 99Mo/99mTc generator was fabricated with UiO-66 (Ce) as adsorbent and its performance was evaluated over two weeks. The elution results showed that 92 ± 3% of 99mTc elution efficiency could be obtained with negligible cerium breakthrough, showing the great potential of UiO-66 (Ce) as adsorbent for 99Mo/99mTc generators.