Print Email Facebook Twitter Design and functional testing of a novel blood pulse wave velocity sensor Title Design and functional testing of a novel blood pulse wave velocity sensor Author van Velzen, M.H.N. (Erasmus MC) Loeve, A.J. (TU Delft Medical Instruments & Bio-Inspired Technology) Mik, E.G. (Erasmus MC) Niehof, S.P. (Erasmus MC) Date 2018 Abstract The multiphotodiode array (MPA) is a novel transmission photoplethysmography (PPG) sensor to measure pulse wave velocity (PWV) in the finger. To validate the MPA, a setup was built to generate a red laser dot traveling over the MPA with known and constant scanning velocities. These scanning velocities were chosen to include speeds at least twice as high as those found in the normal range of PWV in healthy populations and were set at 12.9, 25.8, 36, or 46.7 m/s. The aim of this study was to verify the functionality of the MPA: performing local noninvasive PWV measurements. To illustrate the applicability of the MPA in clinical practice, an in vivo pilot study was conducted using the flow-mediated dilation (FMD) technique. The in vitro accuracy of the MPA was ±0.2%, 0.3%, 0.5%, and 0.6% at the applied scanning velocities. The MPA can measure PWVs with a maximum deviation of 3.0%. The in vivo pilot study showed a PWV before the FMD of 1.1±0.2 m/s. These results suggest that this novel MPA can reliably and accurately measure PWV within clinically relevant ranges and even well beyond. Subject Arterial stiffnessPhotoplethysmography (PPG)Pulse wave velocity (PWV) To reference this document use: http://resolver.tudelft.nl/uuid:2e68df6d-168d-431e-9745-3807cfbdaea2 DOI https://doi.org/10.1115/1.4038308 Embargo date 2018-05-22 ISSN 1932-6181 Source Journal of Medical Devices, 12 (1) Bibliographical note Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public. Part of collection Institutional Repository Document type journal article Rights © 2018 M.H.N. van Velzen, A.J. Loeve, E.G. Mik, S.P. Niehof Files PDF med_012_01_011006.pdf 1.34 MB Close viewer /islandora/object/uuid:2e68df6d-168d-431e-9745-3807cfbdaea2/datastream/OBJ/view