Methyltransferases

Title

Methyltransferases: Functions and Applications

 Author

Abdelraheem, E.M.M. (TU Delft BT/Biocatalysis) ORCID 0000-0002-9008-2729
Thair, Benjamin (University College London)
Varela, Romina Fernández (Universidad Nacional de Quilmes, Bernal and Concet)
Jockmann, Emely (Albert-Ludwigs-Universität Freiburg)
Popadić, Désirée (Albert-Ludwigs-Universität Freiburg)
Hailes, Helen C. (University College London)
Ward, John M. (University College London)
Hagedoorn, P.L. (TU Delft BT/Biocatalysis) ORCID 0000-0001-6342-2022
Hanefeld, U. (TU Delft BT/Biocatalysis) ORCID 0000-0002-4102-6165

 Date

2022

 Abstract

In this review the current state-of-the-art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given.


 Subject

biocatalysis
enzymes
methyltransferases
S-adenosyl-l-methionine

 To reference this document use:

http://resolver.tudelft.nl/uuid:44b8e994-1028-46eb-846a-70cf75ce0a21

 DOI

https://doi.org/10.1002/cbic.202200212

 ISSN

1439-4227

 Source

ChemBioChem: a European journal of chemical biology, 23 (18)

 Part of collection

Institutional Repository

 Document type

review

 Rights

© 2022 E.M.M. Abdelraheem, Benjamin Thair, Romina Fernández Varela, Emely Jockmann, Désirée Popadić, Helen C. Hailes, John M. Ward, P.L. Hagedoorn, U. Hanefeld, More Authors
Files
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