Print Email Facebook Twitter Reproducibility of Natural Shear Wave Elastography Measurements Title Reproducibility of Natural Shear Wave Elastography Measurements Author Keijzer, L.B.H. (Erasmus MC) Strachinaru, Mihai (Erasmus MC) Bowen, Dan J. (Erasmus MC) Geleijnse, Marcel L. (Erasmus MC) van der Steen, A.F.W. (Erasmus MC) Bosch, Johan G. (Erasmus MC) de Jong, N. (TU Delft ImPhys/Acoustical Wavefield Imaging; Erasmus MC) Vos, H.J. (TU Delft ImPhys/Acoustical Wavefield Imaging; Erasmus MC) Date 2019 Abstract For the quantification of myocardial function, myocardial stiffness can potentially be measured non-invasively using shear wave elastography. Clinical diagnosis requires high precision. In 10 healthy volunteers, we studied the reproducibility of the measurement of propagation speeds of shear waves induced by aortic and mitral valve closure (AVC, MVC). Inter-scan was slightly higher but in similar ranges as intra-scan variability (AVC: 0.67 m/s (interquartile range [IQR]: 0.40–0.86 m/s) versus 0.38 m/s (IQR: 0.26–0.68 m/s), MVC: 0.61 m/s (IQR: 0.26–0.94 m/s) versus 0.26 m/s (IQR: 0.15–0.46 m/s)). For AVC, the propagation speeds obtained on different day were not statistically different (p = 0.13). We observed different propagation speeds between 2 systems (AVC: 3.23–4.25 m/s [Zonare ZS3] versus 1.82–4.76 m/s [Philips iE33]), p = 0.04). No statistical difference was observed between observers (AVC: p = 0.35). Our results suggest that measurement inaccuracies dominate the variabilities measured among healthy volunteers. Therefore, measurement precision can be improved by averaging over multiple heartbeats. Subject ElastographyHigh frame rateNatural shear wave elastographyShear wavesstiffnessTissue elasticity imagingValve closure To reference this document use: http://resolver.tudelft.nl/uuid:47047a66-4e71-4c25-ac76-502e98165bed DOI https://doi.org/10.1016/j.ultrasmedbio.2019.09.002 ISSN 0301-5629 Source Ultrasound in Medicine & Biology, 45 (12), 3172-3185 Part of collection Institutional Repository Document type journal article Rights © 2019 L.B.H. Keijzer, Mihai Strachinaru, Dan J. Bowen, Marcel L. Geleijnse, A.F.W. van der Steen, Johan G. Bosch, N. de Jong, H.J. Vos Files PDF 1_s2.0_S0301562919315029_main.pdf 1.96 MB Close viewer /islandora/object/uuid:47047a66-4e71-4c25-ac76-502e98165bed/datastream/OBJ/view