Print Email Facebook Twitter Estimation of Diffusion Properties in Crossing Fiber Bundles Title Estimation of Diffusion Properties in Crossing Fiber Bundles Author Caan, M.W.A. Ganesh Khedoe, H. Poot, D.H.J. Den Dekker, A.J. Olabarriaga, S.D. Grimbergen, K.A. Van Vliet, L.J. Vos, F.M. Faculty Applied Sciences Department Imaging Science and Technology Date 2010-06-17 Abstract There is an ongoing debate on how to model diffusivity in fiber crossings. We propose an optimization framework for the selection of a dual tensor model and the set of diffusion weighting parameters b, such that both the diffusion shape and orientation parameters can be precisely as well as accurately estimated. For that, we have adopted the Cramér-Rao lower bound (CRLB) on the variance of the model parameters, and performed Monte Carlo simulations.We have found that the axial diffusion needs to be constrained, while an isotropic fraction can be modeled by a single parameter fiso. Under these circumstances, the Fractional Anisotropy (FA) of both tensors can theoretically be independently estimated with a precision of 9% (at SNR = 25). Levenberg–Marquardt optimization of the Maximum Likelihood function with a Rician noise model approached this precision while the bias was insignificant. A two-element b-vector [1.0 3.5] . 10³ mm-2s was found to be sufficient for estimating parameters of heterogeneous tissue with low error. This has allowed us to estimate consistent FA-profiles along crossing tracts. This work defines fundamental limits for comparative studies to correctly analyze crossing white matter structures. Subject Cramér-Rao analysisdiffusion propertiesdiffusion weighted magnetic resonance imagingdual tensor modelMonte Carlo simulations To reference this document use: http://resolver.tudelft.nl/uuid:57424b63-f5e0-4800-adab-5f3449ecbdf2 DOI https://doi.org/10.1109/TMI.2010.2049577 Publisher IEEE ISSN 0278-0062 Source IEEE Transactions on Medical Imaging, 29 (8), 2010 Part of collection Institutional Repository Document type journal article Rights (c) 2010 The Author(s)IEEE Files PDF Caan_2010.pdf 853.51 KB Close viewer /islandora/object/uuid:57424b63-f5e0-4800-adab-5f3449ecbdf2/datastream/OBJ/view