Print Email Facebook Twitter Acoustic Characterization of the CLINIcell for Ultrasound Contrast Agent Studies Title Acoustic Characterization of the CLINIcell for Ultrasound Contrast Agent Studies Author Beekers, D.I. (Erasmus MC) van Rooij, Tom (Erasmus MC) van der Steen, A.F.W. (TU Delft ImPhys/Acoustical Wavefield Imaging) de Jong, N. (TU Delft ImPhys/Acoustical Wavefield Imaging) Verweij, M.D. (TU Delft ImPhys/Acoustical Wavefield Imaging) Kooiman, Klazina (Erasmus MC) Date 2018 Abstract Ultrasound contrast agents consist of gas-filled coated microbubbles that oscillate upon ultrasound insonification. Their characteristic oscillatory response provides contrast enhancement for imaging and has the potential to locally enhance drug delivery. Since microbubble response depends on the local acoustic pressure, an ultrasound compatible chamber is needed to study their behavior and the underlying drug delivery pathways. In this study, we determined the amplitude of the acoustic pressure in the CLINIcell, an optically transparent chamber suitable for cell culture. The pressure field was characterized based on microbubble response recorded using the Brandaris 128 ultra-high speed camera and an iterative processing method. The results were compared to a control experiment performed in an OptiCell, which is conventionally used in microbubble studies. Microbubbles in the CLINIcell responded in a controlled manner, comparable to those in the OptiCell. For frequencies from 1 to 4 MHz, the mean pressure amplitude was -5.4 dB with respect to the externally applied field. The predictable ultrasound pressure demonstrates the potential of the CLINIcell as an optical, ultrasound, and cell culture compatible device to study microbubble oscillation behavior and ultrasound-mediated drug delivery. Subject Acoustic characterizationAcousticsBiomedical optical imagingDrug deliverydrug deliveryIntegrated opticsOptical sensorsOptical variables controlultra-high speed imagingUltrasonic imagingultrasound contrast agents To reference this document use: http://resolver.tudelft.nl/uuid:628f36a9-9351-4610-b1c5-13ccbbf3f650 DOI https://doi.org/10.1109/TUFFC.2018.2881724 ISSN 0885-3010 Source IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 66 (1), 244-246 Part of collection Institutional Repository Document type journal article Rights © 2018 D.I. Beekers, Tom van Rooij, A.F.W. van der Steen, N. de Jong, M.D. Verweij, Klazina Kooiman Files PDF 08537987.pdf 3.9 MB Close viewer /islandora/object/uuid:628f36a9-9351-4610-b1c5-13ccbbf3f650/datastream/OBJ/view