Print Email Facebook Twitter Interplay between Confinement and Drag Forces Determine the Fate of Amyloid Fibrils Title Interplay between Confinement and Drag Forces Determine the Fate of Amyloid Fibrils Author Smith, Kathleen Beth (ETH Zürich) Wehrli, Monika (ETH Zürich) Japaridze, A. (TU Delft BN/Cees Dekker Lab; Kavli institute of nanoscience Delft) Assenza, Salvatore (ETH Zürich) Dekker, C. (TU Delft BN/Cees Dekker Lab; Kavli institute of nanoscience Delft) Mezzenga, Raffaele (ETH Zürich) Date 2020 Abstract The fine interplay between the simultaneous stretching and confinement of amyloid fibrils is probed by combining a microcapillary setup with atomic force microscopy. Single-molecule statistics reveal how the stretching of fibrils changed from force to confinement dominated at different length scales. System order, however, is solely ruled by confinement. Coarse-grained simulations support the results and display the potential to tailor system properties by tuning the two effects. These findings may further help shed light on in vivo amyloid fibril growth and transport in highly confined environments such as blood vessels. To reference this document use: http://resolver.tudelft.nl/uuid:69753852-d305-4289-afb5-6bf0ab4efbfd DOI https://doi.org/10.1103/PhysRevLett.124.118102 ISSN 0031-9007 Source Physical Review Letters, 124 (11) Part of collection Institutional Repository Document type journal article Rights © 2020 Kathleen Beth Smith, Monika Wehrli, A. Japaridze, Salvatore Assenza, C. Dekker, Raffaele Mezzenga Files PDF PhysRevLett.124.118102.pdf 1.68 MB Close viewer /islandora/object/uuid:69753852-d305-4289-afb5-6bf0ab4efbfd/datastream/OBJ/view