Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

Title

Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

 Author

Höfler, G.T. (TU Delft BT/Biocatalysis)
But, A. (TU Delft BT/Biocatalysis) ORCID 0000-0002-1157-3774
Younes, S.H.H. (TU Delft BT/Biocatalysis; Sohag University)
Wever, Ron (Universiteit van Amsterdam)
Paul, C.E. (TU Delft BT/Biocatalysis) ORCID 0000-0002-7889-9920
Arends, I.W.C.E. (Universiteit Utrecht) ORCID 0000-0002-1015-4682
Hollmann, F. (TU Delft BT/Biocatalysis) ORCID 0000-0003-4821-756X

 Date

2020

 Abstract

The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.


 Subject

Chemoenzymatic halocyclization
Haloperoxidase
Preparative scale

 To reference this document use:

http://resolver.tudelft.nl/uuid:6f587aa9-4786-4746-8835-77ef0d591715

 DOI

https://doi.org/10.1021/acssuschemeng.9b07494

 ISSN

2168-0485

 Source

ACS Sustainable Chemistry and Engineering, 8 (7), 2602-2607

 Part of collection

Institutional Repository

 Document type

journal article

 Rights

© 2020 G.T. Höfler, A. But, S.H.H. Younes, Ron Wever, C.E. Paul, I.W.C.E. Arends, F. Hollmann
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