Print Email Facebook Twitter Possible alleviation of symptoms and side effects through clinicians' nocebo information and empathy in an experimental video vignette study Title Possible alleviation of symptoms and side effects through clinicians' nocebo information and empathy in an experimental video vignette study Author Meijers, M. C. (Universiteit Leiden) Stouthard, J. (Netherlands Cancer Institute) Evers, A.W.M. (TU Delft Applied Ergonomics and Design; TU Delft HR Health; Universiteit Leiden) Das, E. (Radboud Universiteit Nijmegen) Drooger, H. J. (Universiteit Leiden) Jansen, S. J.A.J. (Universiteit Leiden) Francke, A. L. (Netherlands Institute of Health Services Research) Plum, N. (University Medical Center Utrecht) van Vliet, L. M. (Universiteit Leiden) Date 2022 Abstract To alleviate anti-cancer treatment burden in advanced breast cancer, patient-clinician communication strategies based on nocebo-effect mechanisms are promising. We assessed distinct/combined effects on psychological outcomes (e.g. anxiety; main outcome) and side-effect expectations of (1) nocebo information about the (non)pharmacological origin of side effects, and (2) clinician-expressed empathy through reassurance of continuing support. Furthermore, we explored whether information and empathy effects on side-effect expectations were mediated by decreased anxiety. In a two-by-two experimental video-vignette design, 160 cancer patients/survivors and healthy women watched one of four videos differing in level of nocebo information (±) and empathy (±). Regression and mediation analysis were used to determine effects of information/empathy and explore anxiety's mediating role. Anxiety was not influenced by empathy or information (Stai-state: p = 0.295; p = 0.390, VAS p = 0.399; p = 0.823). Information improved (specific) side-effect coping expectations (p < 0.01). Empathy improved side-effect intensity expectations (p < 0.01 = specific; p < 0.05 = non-specific/partial) and specific side-effect probability expectations (p < 0.01), and increased satisfaction, trust, and self-efficacy (p < 0.001). No mediating effects were found of anxiety on expectations. Mainly empathy, but also nocebo information improved psychological outcomes and-mainly specific-side-effect expectations. Exploring the power of these communication elements in clinical practice is essential to diminish the anti-cancer treatment burden in advanced breast cancer. To reference this document use: http://resolver.tudelft.nl/uuid:750b5abb-cf02-47aa-a8c8-f590ba6997a9 DOI https://doi.org/10.1038/s41598-022-19729-w ISSN 2045-2322 Source Scientific Reports, 12 (1) Part of collection Institutional Repository Document type journal article Rights © 2022 M. C. Meijers, J. Stouthard, A.W.M. Evers, E. Das, H. J. Drooger, S. J.A.J. Jansen, A. L. Francke, N. Plum, L. M. van Vliet, More Authors Files PDF s41598_022_19729_w.pdf 1.1 MB Close viewer /islandora/object/uuid:750b5abb-cf02-47aa-a8c8-f590ba6997a9/datastream/OBJ/view