Artificial Biocatalysis

Title

Artificial Biocatalysis: Quo Vadis?

 Author

Ingram, A.A. (TU Delft BT/Biocatalysis)
Oike, K. (TU Delft BT/Biocatalysis)

Date

2024

 Abstract

Astonishing progress has been achieved in unlocking new-to-nature biocatalysis in the past decades. The progress in protein engineering enabled research to efficiently incorporate artificial structural elements into enzyme design. Recent trends include cofactor mimetics, artificial metalloenzymes and non-canonical amino acids. In this perspective article, we present the state-of-the-art, discuss recent examples and our view on what we call artificial biocatalysis. Although these artificial systems undoubtedly increase the scope of biocatalysis, their applicability remains challenging. Fundamental questions regarding the impact of this research field are addressed in this perspective.


 Subject

Artificial metalloenzymes
Biocatalysis
Directed evolution
non-canonical amino acids
Protein engineering

 To reference this document use:

http://resolver.tudelft.nl/uuid:798cacc3-f212-4216-9098-08658de273d5

 DOI

https://doi.org/10.1002/cctc.202301759

 ISSN

1867-3880

 Source

ChemCatChem

 Part of collection

Institutional Repository

 Document type

journal article

 Rights

© 2024 A.A. Ingram, K. Oike
Files
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