Print Email Facebook Twitter Hypericin Title Hypericin: Source, Determination, Separation, and Properties Author Zhang, Jie (Chongqing Technology and Business University) Gao, Ling (Chongqing Technology and Business University) Hu, Jie (Chongqing Technology and Business University) Wang, Chongjun (Chongqing Technology and Business University) Hagedoorn, P.L. (TU Delft BT/Biocatalysis) Li, Ning (Chongqing Technology and Business University) Zhou, Xing (Chongqing Academy of Chinese Materia Medica, Chongqing) Date 2020 Abstract Hypericin is a naturally occurring compound synthesized by certain species of the genus Hypericum, with various pharmacological effects. It is used as a natural photosensitizing agent with great potential in photodynamic therapy. This review discusses the latest results about the biosynthetic pathways and chemical synthetic routes to obtain hypericin. Although many analysis methods can be used for the determination of hypericin purity, HPLC has become the method of choice due to its fast and sensitive analyses. The extraction and purification of hypericin are also described. Hypericin can be used as a photosensitizer due to a large and active π-electron conjugated system in its structure. Medical applications of hypericin are not easy due to several unsolved practical problems, which include hypericin phototoxicity, poor solubility in water, and extreme sensitivity to light, heat, and pH. Subject extractionHypericinphotosensitivitysolubilitystabilitysynthesis To reference this document use: http://resolver.tudelft.nl/uuid:7f0ae54b-520f-43b7-84a1-839559423792 DOI https://doi.org/10.1080/15422119.2020.1797792 ISSN 1542-2119 Source Separation and Purification Reviews, 51 (1), 1-10 Part of collection Institutional Repository Document type journal article Rights © 2020 Jie Zhang, Ling Gao, Jie Hu, Chongjun Wang, P.L. Hagedoorn, Ning Li, Xing Zhou Files PDF Hypericin_Source_Determin ... erties.pdf 734.04 KB Close viewer /islandora/object/uuid:7f0ae54b-520f-43b7-84a1-839559423792/datastream/OBJ/view