A 256 pixel magnetoresistive biosensor microarray in 0.18μm CMOS

Journal article (2013)

Authors

Drew A. Hall Stanford University
Richard S. Gaster Stanford University
K.A.A. Makinwa Electronic Instrumentation - EEMCS
Shan X. Wang Stanford University
B. Murmann Stanford University
Research Group
Electronic Instrumentation (EEMCS) (TU Delft)
Copyright: © 2013 Drew A. Hall, Richard S. Gaster, K.A.A. Makinwa, Shan X. Wang, Boris Murmann
DOI: https://doi.org/10.1109/JSSC.2013.2245058
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Published Date

2013

Language

English

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Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Microelectronics

Research Group

Electronic Instrumentation

Abstract

Magnetic nanotechnologies have shown significant potential in several areas of nanomedicine such as imaging, therapeutics, and early disease detection. Giant magnetoresistive spin-valve (GMR SV) sensors coupled with magnetic nanotags (MNTs) possess great promise as ultra-sensitive biosensors for diagnostics. We report an integrated sensor interface for an array of 256 GMR SV biosensors designed in 0.18 μm CMOS. Arranged like an imager, each of the 16 column level readout channels contains an analog frontend and a compact ΣΔ modulator (0.054 mm2) with 84 dB of dynamic range and an input referred noise of 49
nT/√Hz. Performance is demonstrated through detection of an ovarian cancer biomarker, secretory leukocyte peptidase inhibitor (SLPI), spiked at concentrations as low as 10 fM. This system is designed as a replacement
for optical protein microarrays while also providing real-time kinetics monitoring.