Title
Additively manufactured biodegradable porous iron
Author
Li, Y. (TU Delft Biomaterials & Tissue Biomechanics) 
Jahr, H. (Medizinische Fakultat und Universitats Klinikum Aachen; Maastricht UMC)
Lietaert, K. (Katholieke Universiteit Leuven; 3D Systems)
Pavanram, P. (Medizinische Fakultat und Universitats Klinikum Aachen)
Yilmaz, A. (TU Delft (OLD) MSE-6)
Fockaert, L.I. (TU Delft (OLD) MSE-6)
Leeflang, M.A. (TU Delft Biomaterials & Tissue Biomechanics)
Pouran, B. (TU Delft Biomaterials & Tissue Biomechanics; University Medical Center Utrecht)
Gonzalez Garcia, Y. (TU Delft (OLD) MSE-6)
Weinans, Harrie (TU Delft Biomaterials & Tissue Biomechanics; University Medical Center Utrecht)
Mol, J.M.C. (TU Delft (OLD) MSE-6)
Zhou, J. (TU Delft Biomaterials & Tissue Biomechanics)
Zadpoor, A.A. (TU Delft Biomaterials & Tissue Biomechanics)
Date
2018
Abstract
Additively manufactured (AM) topologically ordered porous metallic biomaterials with the proper biodegradation profile offer a unique combination of properties ideal for bone regeneration. These include a fully interconnected porous structure, bone-mimicking mechanical properties, and the possibility of fully regenerating bony defects. Most of such biomaterials are, however, based on magnesium and, thus, degrade too fast. Here, we present the first report on topologically ordered porous iron made by Direct Metal Printing (DMP). The topological design was based on a repetitive diamond unit cell. We conducted a comprehensive study on the in vitro biodegradation behavior (up to 28 days), electrochemical performance, time-dependent mechanical properties, and biocompatibility of the scaffolds. The mechanical properties of AM porous iron (E = 1600–1800 MPa) were still within the range of the values reported for trabecular bone after 28 days of biodegradation. Electrochemical tests showed up to ≈12 times higher rates of biodegradation for AM porous iron as compared to that of cold-rolled (CR) iron, while only 3.1% of weight loss was measured after 4 weeks of immersion tests. The biodegradation mechanisms were found to be topology-dependent and different between the periphery and central parts of the scaffolds. While direct contact between MG-63 cells and scaffolds revealed substantial and almost instant cytotoxicity in static cell culture, as compared to Ti-6Al-4V, the cytocompatibility according to ISO 10993 was reasonable in in vitro assays for up to 72 h. This study shows how DMP could be used to increase the surface area and decrease the grain sizes of topologically ordered porous metallic biomaterials made from metals that are usually considered to degrade too slowly (e.g., iron), opening up many new opportunities for the development of biodegradable metallic biomaterials. Statement of Significance: Biodegradation in general and proper biodegradation profile in particular are perhaps the most important requirements that additively manufactured (AM) topologically ordered porous metallic biomaterials should offer in order to become the ideal biomaterial for bone regeneration. Currently, most biodegradable metallic biomaterials are based on magnesium, which degrade fast with gas generation. Here, we present the first report on topologically ordered porous iron made by Direct Metal Printing (DMP). We also conducted a comprehensive study on the biodegradation behavior, electrochemical performance, biocompatibility, and the time evolution of the mechanical properties of the implants. We show that these implants possess bone-mimicking mechanical properties, accelerated degradation rate, and reasonable cytocompatibility, opening up many new opportunities for the development of iron-based biodegradable materials.
Subject
Additive manufacturing
Biocompatibility
Biodegradation
Direct metal printing
Iron scaffolds
Mechanical property
To reference this document use:
http://resolver.tudelft.nl/uuid:9e5b9432-23dd-4417-9cbd-45ec02c7535c
DOI
https://doi.org/10.1016/j.actbio.2018.07.011
Embargo date
2019-01-06
ISSN
1742-7061
Source
Acta Biomaterialia, 77, 380-393
Bibliographical note
Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.
Part of collection
Institutional Repository
Document type
journal article
Rights
© 2018 Y. Li, H. Jahr, K. Lietaert, P. Pavanram, A. Yilmaz, L.I. Fockaert, M.A. Leeflang, B. Pouran, Y. Gonzalez Garcia, Harrie Weinans, J.M.C. Mol, J. Zhou, A.A. Zadpoor