Spectroscopic photoacoustic imaging of radiofrequency ablation in the left atrium

Journal article (2018)

Authors

P. Kruizinga , Erasmus MC
G. van Soest Erasmus MC
A.F.W. van der Steen Erasmus MC,
Department
Biomechanical Engineering
Copyright: © 2018 Sophinese Iskander-Rizk, P. Kruizinga, Antonius F.W. Van Der Steen, G. van Soest, A.F.W. van der Steen
DOI: https://doi.org/10.1364/BOE.9.001309
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Published Date

2018

Language

English

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Department

Biomechanical Engineering

Abstract

Catheter-based radiofrequency ablation for atrial fibrillation has long-term success in 60-70% of cases. A better assessment of lesion quality, depth, and continuity could improve the procedure’s outcome. We investigate here photoacoustic contrast between ablated and healthy atrial-wall tissue in vitro in wavelengths spanning from 410 nm to 1000 nm. We studied single-and multi-wavelength imaging of ablation lesions and we demonstrate that a two-wavelength technique yields precise detection of lesions, achieving a diagnostic accuracy of 97%. We compare this with a best single-wavelength (640 nm) analysis that correctly identifies 82% of lesions. We discuss the origin of relevant spectroscopic features and perspectives for translation to clinical imaging.

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