Title
Changes in Health-Related Quality of Life following Surgery in Patients with High-Grade Extremity Soft-Tissue Sarcoma: A Prospective Longitudinal Study
Author
Kruiswijk, Anouk (Leiden University Medical Center)
Sande, MAJ van de (Leiden University Medical Center)
Verhoef, Cornelis (Erasmus MC)
Schrage, Yvonne M. (Netherlands Cancer Institute)
Haas, Rick L (Netherlands Cancer Institute; Leiden University Medical Center)
Bemelmans, Marc H. A. (Maastricht University Medical Center)
van Ginkel, Robert J. (University Medical Center Groningen)
Bonenkamp, Johannes J. (Radboud University Medical Center)
Witkamp, Arjen J. (University Medical Center Utrecht)
van den Akker-van Marle, M. Elske (Leiden University Medical Center)
Marang-van de Mheen, P.J. (TU Delft Safety and Security Science) ![ORCID 0000-0003-1439-0989 ORCID 0000-0003-1439-0989](/sites/all/themes/tud_repo3/img/icons/orcid_16x16.png)
van Bodegom-Vos, Leti (Leiden University Medical Center)
Date
2024
Abstract
Introduction: Changes in health-related quality of life (HRQoL) during the diagnostic and treatment trajectory of high-grade extremity soft-tissue sarcoma (eSTS) has rarely been investigated for adults (18–65 y) and the elderly (aged ≥65 y), despite a potential variation in challenges from diverse levels of physical, social, or work-related activities. This study assesses HRQoL from time of diagnosis to one year thereafter among adults and the elderly with eSTS. Methods: HRQoL of participants from the VALUE-PERSARC trial (n = 97) was assessed at diagnosis and 3, 6 and 12 months thereafter, utilizing the PROMIS Global Health (GH), PROMIS Physical Function (PF) and EQ-5D-5L. Results: Over time, similar patterns were observed in all HRQoL measures, i.e., lower HRQoL scores than the Dutch population at baseline (PROMIS-PF:46.8, PROMIS GH-Mental:47.3, GH-Physical:46.2, EQ-5D-5L:0.76, EQ-VAS:72.6), a decrease at 3 months, followed by an upward trend to reach similar scores as the general population at 12 months (PROMIS-PF:49.9, PROMIS GH-Physical:50.1, EQ-5D-5L:0.84, EQ-VAS:81.5), except for the PROMIS GH-Mental (47.5), where scores remained lower than the general population mean (T = 50). Except for the PROMIS-PF, no age-related differences were observed. Conclusions: On average, eSTS patients recover well physically from surgery, yet the mental component demonstrates no progression, irrespective of age. These results underscore the importance of comprehensive care addressing both physical and mental health.
Subject
soft-tissue sarcoma
extremity
Health-related quality of life
physical functioning
mental health
To reference this document use:
http://resolver.tudelft.nl/uuid:b917963e-f07c-420a-b163-47c4703d73ea
DOI
https://doi.org/10.3390/cancers16030547
ISSN
2072-6694
Source
Cancers, 16 (3), 547
Part of collection
Institutional Repository
Document type
journal article
Rights
© 2024 Anouk Kruiswijk, MAJ van de Sande, Cornelis Verhoef, Yvonne M. Schrage, Rick L Haas, Marc H. A. Bemelmans, Robert J. van Ginkel, Johannes J. Bonenkamp, Arjen J. Witkamp, M. Elske van den Akker-van Marle, P.J. Marang-van de Mheen, Leti van Bodegom-Vos