Print Email Facebook Twitter Surfing the wave of oxyfunctionalization chemistry by engineering fungal unspecific peroxygenases Title Surfing the wave of oxyfunctionalization chemistry by engineering fungal unspecific peroxygenases Author Beltrán-Nogal, Alejandro (University of the Balearic Islands) Sánchez-Moreno, Israel (University of the Balearic Islands) Méndez-Sánchez, Daniel (University of the Balearic Islands) Gómez de Santos, Patricia (Evoenzyme S.L., Madrid) Hollmann, F. (TU Delft BT/Biocatalysis) Alcalde, Miguel (University of the Balearic Islands) Date 2022 Abstract The selective insertion of oxygen into non-activated organic molecules has to date been considered of utmost importance to synthesize existing and next generation industrial chemicals or pharmaceuticals. In this respect, the minimal requirements and high activity of fungal unspecific peroxygenases (UPOs) situate them as the jewel in the crown of C–H oxyfunctionalization biocatalysts. Although their limited availability and development has hindered their incorporation into industry, the conjunction of directed evolution and computational design is approaching UPOs to practical applications. In this review, we will address the most recent advances in UPO engineering, both of the long and short UPO families, while discussing the future prospects in this fast-moving field of research. To reference this document use: http://resolver.tudelft.nl/uuid:d410d119-83da-457c-95d2-74061f32bbe5 DOI https://doi.org/10.1016/j.sbi.2022.102342 ISSN 0959-440X Source Current Opinion in Structural Biology, 73 Part of collection Institutional Repository Document type review Rights © 2022 Alejandro Beltrán-Nogal, Israel Sánchez-Moreno, Daniel Méndez-Sánchez, Patricia Gómez de Santos, F. Hollmann, Miguel Alcalde Files PDF 1_s2.0_S0959440X2200015X_main.pdf 1.54 MB Close viewer /islandora/object/uuid:d410d119-83da-457c-95d2-74061f32bbe5/datastream/OBJ/view