Print Email Facebook Twitter Setting your clock Title Setting your clock: associations between timing of objective physical activity and cardiovascular disease risk in the general population Author Albalak, Gali (Leiden University Medical Center) Stijntjes, M. (TU Delft Support Biomechanical Engineering; Leiden University Medical Center) van Bodegom, David (Leiden University Medical Center; Leyden Academy on Vitality and Ageing) Jukema, J. Wouter (Leiden University Medical Center; Netherlands Heart Institute) Atsma, Douwe E. (Leiden University Medical Center) van Heemst, Diana (Leiden University Medical Center) Noordam, Raymond (Leiden University Medical Center) Date 2023 Abstract Aims Little is known about the impact of daily physical activity timing (here referred to as 'chronoactivity') on cardiovascular disease (CVD) risk. We aimed to examined the associations between chronoactivity and multiple CVD outcomes in the UK Biobank. Methods and results physical activity data were collected in the UK-Biobank through triaxial accelerometer over a 7-day measurement period. We used K-means clustering to create clusters of participants with similar chronoactivity irrespective of the mean daily intensity of the physical activity. Multivariable-adjusted Cox-proportional hazard models were used to estimate hazard ratios (HRs) comparing the different clusters adjusted for age and sex (model 1), and baseline cardiovascular risk factors (model 2). Additional stratified analyses were done by sex, mean activity level, and self-reported sleep chronotype. We included 86 657 individuals (58% female, mean age: 61.6 [SD: 7.8] years, mean BMI: 26.6 [4.5] kg/m2). Over a follow-up period of 6 years, 3707 incident CVD events were reported. Overall, participants with a tendency of late morning physical activity had a lower risk of incident coronary artery disease (HR: 0.84, 95%CI: 0.77, 0.92) and stroke (HR: 0.83, 95%CI: 0.70, 0.98) compared to participants with a midday pattern of physical activity. These effects were more pronounced in women (P-value for interaction=0.001). We did not find evidence favouring effect modification by total activity level and sleep chronotype. Conclusion Irrespective of total physical activity, morning physical activity was associated with lower risks of incident cardiovascular diseases, highlighting the potential importance of chronoactivity in CVD prevention. Subject ChronoactivityCoronary artery diseasePatternsPhysical activityStroke To reference this document use: http://resolver.tudelft.nl/uuid:d7121d2b-f429-4c47-a918-02511d2604df DOI https://doi.org/10.1093/eurjpc/zwac239 ISSN 2047-4873 Source European journal of preventive cardiology, 30 (3), 232-240 Part of collection Institutional Repository Document type journal article Rights © 2023 Gali Albalak, M. Stijntjes, David van Bodegom, J. Wouter Jukema, Douwe E. Atsma, Diana van Heemst, Raymond Noordam Files PDF zwac239.pdf 667.68 KB Close viewer /islandora/object/uuid:d7121d2b-f429-4c47-a918-02511d2604df/datastream/OBJ/view