Optical detection of electrokinetically manipulated single molecules in a nanofluidic chip

Parikesit, G.O.F.; Kutchoukov, V.G.; Bossche, A.; Young, I.T.; Garini, Y.

Optical detection of electrokinetically manipulated single molecules in a nanofluidic chip

Title

Optical detection of electrokinetically manipulated single molecules in a nanofluidic chip

Author

Parikesit, G.O.F.
Kutchoukov, V.G.
Bossche, A.
Young, I.T.
Garini, Y.

Faculty

Applied Sciences

Department

Quantitative Imaging Group

Date

2005-01-22

Abstract

We report on the progress of a novel nanofluidic device for detecting and manipulating single molecules in solution. This paper discusses the development of an earlier proposed molecule separation method, where electrokinetic forces separate different molecules based on their masses and charges. Optical imaging using confocal microscopy is applied to perform the detection of the single molecules. Potential applications of this device will be assessed. This research aims for the high spatial and spectral resolutions, both in manipulation and detection, which can lead to molecular identification.

Subject

optical detection
nanofluidics
single molecules
lab on a chip
molecular identification

To reference this document use:

http://resolver.tudelft.nl/uuid:de6ad71a-3f7d-4331-91a8-9ed4680a718d

Publisher

SPIE

ISSN

0277-786X

Source

Proceedings of SPIE, 2005 vol. 5718

Part of collection

Institutional Repository