Print Email Facebook Twitter Kidney Stones in μ-Reactors Title Kidney Stones in μ-Reactors: Design/production of microfluidic devices for induction time experiments and a comparison between laboratory and micro scale reactors Author Yu, Tsun (TU Delft Applied Sciences) Contributor Eral, Burak (mentor) Ibis, Fatma (mentor) Degree granting institution Delft University of Technology Programme Chemical Engineering Date 2019-11-21 Abstract Kidney stones disease is a serious healthy issue in modern society. The amount of patients getting kidney stones are increasing every year. This trend can be caused my numerous reasons like dietary and living conditions. The main point is that the number of kidney stone disease patients need to be lowered. The first step to achieve this is by getting a better understanding of the process of kidney stone formation. The focus will be on calcium oxalate which is the main constituent of kidney stones. In this study we present a microfluidic method to quantify nucleation kinetics of calcium oxalate as function of supersaturation, pH and in the presence of inhibitors (Magnesium, Osteopontin). We have optimized the design of the microfluidic device to minimize the droplet coalescence. Kinetic parameters were obtained through fitting of the probability of nucleation curves measured for over a hundred microdroplets. Nucleation kinetics was seen to increase with an increase in supersaturation, as expected. At pH 6.0 the kinetics dramatically slows down compared to pH’s 3.6 and 8.6. As the inhibitor concentration increases the kinetics will decrease, this is the case for both magnesium and osteopontin. To reference this document use: http://resolver.tudelft.nl/uuid:ed56b44e-1ed7-4c6e-a06c-6b57d47c693e Part of collection Student theses Document type master thesis Rights © 2019 Tsun Yu Files PDF report.pdf 13.12 MB Close viewer /islandora/object/uuid:ed56b44e-1ed7-4c6e-a06c-6b57d47c693e/datastream/OBJ/view